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Enkephalin (2-D-Alanine-5-D-Leucine), [Tyrosyl-3,5-3H(N)]-, 250µCi (9.25MBq)

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珀金埃爾默醫(yī)學(xué)診斷產(chǎn)品（上海）有限公司

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產(chǎn)品簡介

DADLE, tritiated on the tyrosyl group. Peptide sequence: Tyr-D-Ala-Gly-L-Phe-D-Leu. DADLE is a synthetic enkephalin analog considered selective for the delta opioid receptor, but has been shown to bin......

詳細介紹

DADLE acts as an agonist at delta opioid receptors (DOR), but has also been shown to bind mu opioid receptors (MOR). These receptors are a group of GPCRs that are potential drug targets for pain and drug addiction.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET648:

Vo?ahlíková, M., Jurkiewicz, P., Roubalová, L. et al. (2014), High- and low-affinity sites for sodium in δ-OR-Gi1α (Cys351-Ile351) fusion protein stably expressed in HEK293 cells; functional significance and correlation with biophysical state of plasma membrane. Naunyn-Schmiedeberg's Arch Pharmacol, 387: 487.
Bourova, L., Kostrnova, A., Hejnova, L., Moravcova, Z., Moon, H.-E., Novotny, J., Milligan, G. and Svoboda, P. (2003), δ-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains. Journal of Neurochemistry, 85: 34–49.

規(guī)格

濃度	1.0 - 10 mCi/mL
檢測方法	Radiometric
標簽位置	Nominally Labeled
分子量	569.7
產(chǎn)品品牌名稱	NEN Radiochemicals
放射性同位素	H-3
放射性核素	³H
受體類型	Opioid
運輸條件	干冰
特殊訂購信息	This is a radioactive product - shipping address must have a license to receive radioactive materials.
治療領(lǐng)域	CNS & Neurologic, Pain, Inflammation
產(chǎn)品尺寸	250 µCi